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The interestingness calculation needs to incorporate:
large variants (>5kb, or configurable length)
SNP from the list of 'known resistance mutations'
NSY SNP/indel that phylogenetically converges in some meta-data field, for example DR. At the time of writing you don't have this information.
NSY SNP/indel that has multiple independent evolutions in the phylogeny
NSY SNP/indel not accounted in any other rule
Rare SNP/indel (only occurs in <5% of strains). I don't know whether this is interesting or absolutely not, could go at bottom or top of the list. Number needs to be config option.
Common SNP/indel (occurs in >75% of strains). I don't know whether this is interesting or absolutely not, could go at bottom or top of the list. Number needs to be config option.
NSY SNP/indel that is phylogenetically inherited, i.e. only present in strains that come from the same ancestor